Recombinant Human Histone deacetylase 6 (HDAC6), Truncated

Explore the world of epigenetics and nuclear signaling with our Recombinant Human HDAC6, a highly specific histone deacetylase 6 known for its roles in chromatin remodeling, gene expression regulation, and cellular processes. As a key player in these vital mechanisms, HDAC6 is an invaluable protein for researchers seeking to elucidate the complex networks governing cell function and regulation. Our Recombinant Human HDAC6 protein is expressed in an E. coli system, providing a partial protein sequence (1-488 amino acids). The N-terminal 6xHis-SUMO-tag allows for efficient purification and detection in a variety of experimental contexts. With a purity greater than 90% as determined by SDS-PAGE, this recombinant protein ensures consistent results and excellent performance in your research. The product is available in both liquid and lyophilized powder forms to accommodate your specific experimental requirements.

ACP02389

Explore the world of epigenetics and nuclear signaling with our Recombinant Human HDAC6, a highly specific histone deacetylase 6 known for its roles in chromatin remodeling, gene expression regulation, and cellular processes. As a key player in these vital mechanisms, HDAC6 is an invaluable protein for researchers seeking to elucidate the complex networks governing cell function and regulation.
Our Recombinant Human HDAC6 protein is expressed in an E. coli system, providing a partial protein sequence (1-488 amino acids). The N-terminal 6xHis-SUMO-tag allows for efficient purification and detection in a variety of experimental contexts. With a purity greater than 90% as determined by SDS-PAGE, this recombinant protein ensures consistent results and excellent performance in your research. The product is available in both liquid and lyophilized powder forms to accommodate your specific experimental requirements.

Number

Cat.No	ACP02389	Target Name	HDAC6
Form	Liquid or Lyophilized powder	Expression System	E.coli
Expression Range	1-488aa	Mol Weight	70.1 kDa
Protein Length	Partial	Purity	Greater than 90% as determined by SDS-PAGE.
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP02389

Target Name

HDAC6

Form

Liquid or Lyophilized powder

Expression System

E.coli

Expression Range

1-488aa

Mol Weight

70.1 kDa

Protein Length

Partial

Purity

Greater than 90% as determined by SDS-PAGE.

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	Q9UBN7

Background Information

Uniprot Id

Q9UBN7
Target Species

Human
Target Name

HDAC6
Target Full Name

Histone deacetylase 6
Target Function

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. In addition to histones, deacetylates other proteins: plays a central role in microtubule-dependent cell motility by mediating deacetylation of tubulin. Promotes deacetylation of CTTN, leading to actin polymerization, promotion of autophagosome-lysosome fusion and completion of autophagy. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. In addition to its protein deacetylase activity, plays a key role in the degradation of misfolded proteins: when misfolded proteins are too abundant to be degraded by the chaperone refolding system and the ubiquitin-proteasome, mediates the transport of misfolded proteins to a cytoplasmic juxtanuclear structure called aggresome. Probably acts as an adapter that recognizes polyubiquitinated misfolded proteins and target them to the aggresome, facilitating their clearance by autophagy.
Target Involvement

Chondrodysplasia with platyspondyly, distinctive brachydactyly, hydrocephaly, and microphthalmia (CDP-PBHM)
Target Subcellular Location

Cytoplasm. Cytoplasm, cytoskeleton. Nucleus. Perikaryon. Cell projection, dendrite. Cell projection, axon.
Target Protein Families

Histone deacetylase family, HD type 2 subfamily
Target Research Area

Epigenetics and Nuclear Signaling
Target Synonyms

CPBHM; FLJ16239; HD 6; HD6; HDAC 6; HDAC6; HDAC6_HUMAN; Histone deacetylase 6 (HD6); Histone deacetylase 6; JM 21; JM21; KIAA0901; OTTHUMP00000032398; OTTHUMP00000197663; PPP1R90; Protein phosphatase 1 regulatory subunit 90
Target Background

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It contains an internal duplication of two catalytic domains which appear to function independently of each other. This protein possesses histone deacetylase activity and represses transcription.

Recombinant Human Histone deacetylase 6 (HDAC6), Truncated

Specifications

Immunogen Information

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