Recombinant Human Histone-lysine N-methyltransferase 2C (KMT2C), Truncated

Uniprot Id

Q8NEZ4

Target Species

Human

Target Name

KMT2C

Target Full Name

Histone-lysine N-methyltransferase 2C

Target Function

Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place. Likely plays a redundant role with KMT2D in enriching H3K4me1 mark on primed and active enhancer elements.

Target Subcellular Location

Nucleus.

Target Protein Families

Class V-like SAM-binding methyltransferase superfamily, Histone-lysine methyltransferase family, TRX/MLL subfamily

Target Tissue Specificity

Highly expressed in testis and ovary, followed by brain and liver. Also expressed in placenta, peripherical blood, fetal thymus, heart, lung and kidney. Within brain, expression was highest in hippocampus, caudate nucleus, and substantia nigra. Not detect

Target Synonyms

Histone-lysine N-methyltransferase MLL3; Homologous to ALR protein; KMT2C; Lysine N-methyltransferase 2C; MLL3; MLL3_HUMAN; Myeloid/lymphoid or mixed-lineage leukemia protein 3; Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog