Recombinant Human Histone-lysine N-methyltransferase SETDB2 (SETDB2)

Cat.No	ACP14629	Target Name	SETDB2
Form	Lyophilized powder	Expression System	Custom Production. Please inquire and provide the desire expression system.
Expression Range	1-719	Protein Length	Full length protein
Purity	>85% (SDS-PAGE)	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP14629

Target Name

SETDB2

Form

Lyophilized powder

Expression System

Custom Production. Please inquire and provide the desire expression system.

Expression Range

1-719

Protein Length

Full length protein

Purity

>85% (SDS-PAGE)

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	Q96T68

Background Information

Uniprot Id

Q96T68
Target Species

Human
Target Name

SETDB2
Target Full Name

Histone-lysine N-methyltransferase SETDB2
Target Function

Histone methyltransferase involved in left-right axis specification in early development and mitosis. Specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). H3K9me3 is a specific tag for epigenetic transcriptional repression that recruits HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Contributes to H3K9me3 in both the interspersed repetitive elements and centromere-associated repeats. Plays a role in chromosome condensation and segregation during mitosis.
Target Subcellular Location

Nucleus. Chromosome.
Target Protein Families

Class V-like SAM-binding methyltransferase superfamily
Target Tissue Specificity

Ubiquitous. Highest expression in heart, testis and ovary.
Target Synonyms

C13orf4; Chromosome 13 open reading frame 4 ; Chronic lymphocytic leukemia deletion region 8; Chronic lymphocytic leukemia deletion region gene 8; Chronic lymphocytic leukemia deletion region gene 8 protein; Clld8; CLLL8; Gm293; H3-K9-HMTase; Histone H3-K9 methyltransferase; Histone-lysine N-methyltransferase SETDB2; KMT1F; Lysine N-methyltransferase 1F; Probable histone-lysine N-methyltransferase H3 lysine-9 specific; SEB2; SET domain bifurcated 2; SET domain protein; bifurcated; 2; SETB2_HUMAN; Setdb2
Target Background

This gene encodes a member of a family of proteins that contain a methyl-CpG-binding domain (MBD) and a SET domain and function as histone methyltransferases. This protein is recruited to heterochromatin and plays a role in the regulation of chromosome segregation. This region is commonly deleted in chronic lymphocytic leukemia. Naturally-occuring readthrough transcription occurs from this gene to the downstream PHF11 (PHD finger protein 11) gene. Alternative splicing results in multiple transcript variants.

Recombinant Human Histone-lysine N-methyltransferase SETDB2 (SETDB2)

Specifications

Immunogen Information

Inquire Recombinant Human Histone-lysine N-methyltransferase SETDB2 (SETDB2) Now

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