Recombinant Human HLA class II histocompatibility antigen, DO alpha chain (HLA-DOA), Truncated

Uniprot Id

P06340

Target Species

Human

Target Name

HLA-DOA

Target Full Name

HLA class II histocompatibility antigen, DO alpha chain

Target Function

Important modulator in the HLA class II restricted antigen presentation pathway by interaction with the HLA-DM molecule in B-cells. Modifies peptide exchange activity of HLA-DM.

Target Subcellular Location

Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Note=Complexes with HLA-DM molecule during intracellular transport and in endosomal/lysosomal compartments. Heterotetramerization is necessary to exit the ER.

Target Protein Families

MHC class II family

Target Synonyms

HLA-DOA; HLA-DNA; HLA-DZAHLA class II histocompatibility antigen; DO alpha chain; MHC DN-alpha; MHC DZ alpha; MHC class II antigen DOA

Target Background

HLA-DOA belongs to the HLA class II alpha chain paralogues. HLA-DOA forms a heterodimer with HLA-DOB. The heterodimer, HLA-DO, is found in lysosomes in B cells and regulates HLA-DM-mediated peptide loading on MHC class II molecules. In comparison with classical HLA class II molecules, this gene exhibits very little sequence variation, especially at the protein level.