Recombinant Human Homeobox protein Hox-A11 (HOXA11)

Uniprot Id

P31270

Target Species

Human

Target Name

HOXA11

Target Full Name

Homeobox protein Hox-A11

Target Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Target Involvement

Radioulnar synostosis with amegakaryocytic thrombocytopenia 1 (RUSAT1)

Target Subcellular Location

Nucleus.

Target Protein Families

Abd-B homeobox family

Target Synonyms

Homeo box 1I; Homeo box A11 ; Homeobox A11; Homeobox protein Hox A11; Homeobox protein Hox-1I; Homeobox protein Hox-A11; Homeobox protein HOXA11; Hox 1I; HOX1; HOX1I ; HOXA11; HXA11_HUMAN

Target Background

In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. This gene is involved in the regulation of uterine development and is required for female fertility. Mutations in this gene can cause radio-ulnar synostosis with amegakaryocytic thrombocytopenia.