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| Cat.No | ACP21819 | Target Name | NOTO |
|---|---|---|---|
| Target Synonyms | notochord homolog; flh; floating head; floating head homolog; Homeobox protein notochord; Not; Not homeodomain protein; Noto; NOTO_HUMAN; notochord homeobox; notochord homolog (Xenopus laevis); Znot | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 1-251 |
| Protein Length | Full length protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | A8MTQ0 |
|---|
Uniprot Id
A8MTQ0
Target Species
Human
Target Name
NOTO
Target Full Name
Homeobox protein notochord
Target Function
Transcription regulator acting downstream of both FOXA2 and Brachyury (T) during notochord development. Required for node morphogenesis. Is essential for cilia formation in the posterior notochord (PNC) and for left-right patterning; acts upstream of FOXJ1 and RFX3 in this process and is required for the expression of various components important for axonemal assembly and function. Plays a role in regulating axial versus paraxial cell fate. Activates the transcription of ciliary proteins C11orf97 homolog, FAM183B and SPACA9 in the embryonic ventral node.
Target Subcellular Location
Nucleus.
Target Synonyms
notochord homolog; flh; floating head; floating head homolog; Homeobox protein notochord; Not; Not homeodomain protein; Noto; NOTO_HUMAN; notochord homeobox; notochord homolog (Xenopus laevis); Znot
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