Recombinant Human Hydroxyacid oxidase 1 (HAO1)

Uniprot Id

Q9UJM8

Target Species

Human

Target Name

HAO1

Target Full Name

2-Hydroxyacid oxidase 1

Target Function

Has 2-hydroxyacid oxidase activity. Most active on the 2-carbon substrate glycolate, but is also active on 2-hydroxy fatty acids, with high activity towards 2-hydroxy palmitate and 2-hydroxy octanoate.

Target Subcellular Location

Peroxisome.

Target Protein Families

FMN-dependent alpha-hydroxy acid dehydrogenase family

Target Tissue Specificity

Liver.

Target Synonyms

(S) 2 hydroxy acid oxidase ; Glycolate oxidase; GOX; GOX1; HAO1; HAOX1; HAOX1_HUMAN; Hydroxyacid oxidase 1; MGC142225; MGC142227; OTTHUMP00000030231

Target Background

This gene is one of three related genes that have 2-hydroxyacid oxidase activity yet differ in encoded protein amino acid sequence, tissue expression and substrate preference. Subcellular location of the encoded protein is the peroxisome. Specifically, this gene is expressed primarily in liver and pancreas and the encoded protein is most active on glycolate, a two-carbon substrate. The protein is also active on 2-hydroxy fatty acids. The transcript detected at high levels in pancreas may represent an alternatively spliced form or the use of a multiple near-consensus upstream polyadenylation site.