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Recombinant Human Hydroxyacid-oxoacid transhydrogenase, mitochondrial (ADHFE1), Truncated

ACP15143

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Specifications

Cat.No	ACP15143	Target Name	ADHFE1
Form	Lyophilized powder	Expression System	Custom Production. Please inquire and provide the desire expression system.
Expression Range	1-467aa	Protein Length	Partial
Purity	>85% (SDS-PAGE)	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information

Target Species	Human	Uniprot ID	Q8IWW8

Background Information

Uniprot Id

Q8IWW8
Target Species

Human
Target Name

ADHFE1
Target Full Name

Hydroxyacid-oxoacid transhydrogenase, mitochondrial
Target Function

Catalyzes the cofactor-independent reversible oxidation of gamma-hydroxybutyrate (GHB) to succinic semialdehyde (SSA) coupled to reduction of 2-ketoglutarate (2-KG) to D-2-hydroxyglutarate (D-2-HG). D,L-3-hydroxyisobutyrate and L-3-hydroxybutyrate (L-3-OHB) are also substrates for HOT with 10-fold lower activities.
Target Subcellular Location

Mitochondrion.
Target Protein Families

Iron-containing alcohol dehydrogenase family, Hydroxyacid-oxoacid transhydrogenase subfamily
Target Tissue Specificity

Only expressed in adult liver.
Target Synonyms

ADH8; ADHFE 1; ADHFe1; Alcohol dehydrogenase iron-containing protein 1; Alcohol dehydrogenase; iron containing; 1; Fe containing alcohol dehydrogenase; Fe-containing alcohol dehydrogenase; HOT; HOT_HUMAN; Hydroxyacid oxoacid transhydrogenase; mitochondrial; Hydroxyacid-oxoacid transhydrogenase; mitochondrial
Target Background

The ADHFE1 gene encodes hydroxyacid-oxoacid transhydrogenase (EC 1.1.99.24), which is responsible for the oxidation of 4-hydroxybutyrate in mammalian tissues (Kardon et al., 2006 [PubMed 16616524]).

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Recombinant Human Hydroxyacid-oxoacid transhydrogenase, mitochondrial (ADHFE1), Truncated

Specifications

Immunogen Information

Inquire Recombinant Human Hydroxyacid-oxoacid transhydrogenase, mitochondrial (ADHFE1), Truncated Now

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