Chinese (Simplified)
English
German
Korean
Spanish
Sign up for an account to enjoy easy online shopping and instant order tracking.
Recombinant human FCGRT is produced by expressing the expression vector that contains the human FCGRT gene segment (24-297aa) and the N-terminal GST-tag gene in E. coli. As confirmed by SDS-PAGE, this high-quality recombinant FCGRT protein achieves over 90% purity and is available in liquid or lyophilized powder forms. Ideal for studies in immunology, this recombinant FCGRT ensures reliable and consistent results for your research needs. The human FCGRT protein is a critical component of the immune system, primarily involved in transporting and regulating immunoglobulin G (IgG) antibodies. It plays a pivotal role in the transcytosis of maternal IgG across the placenta, facilitating passive immunity from mother to fetus [3][4]. FCGRT operates through a pH-dependent mechanism, exhibiting a high affinity for IgG at acidic pH levels, such as those found in endosomes while releasing IgG at neutral pH, typical of the extracellular environment [3][5]. This property is essential for maintaining serum IgG levels and prolonging the half-life of IgG antibodies in circulation, which is crucial for effective immune responses [2][5]. Additionally, FCGRT is involved in recycling IgG and albumin, contributing to their homeostasis within the body [1][6]. References:[1] S. Reznik, A. Tiwari, & C. Ashby, Efgartigimod, an fcrn antagonist, as a potential treatment for post covid-19 syndrome, Acta Materia Medica, vol. 2, no. 2, 2023. https://doi.org/10.15212/amm-2023-0004[2] M. Babamohamadi, Anti-ctla-4 nanobody as a promising approach in cancer immunotherapy, Cell Death and Disease, vol. 15, no. 1, 2024. https://doi.org/10.1038/s41419-023-06391-x[3] D. Ferguson and J. Blanco, Regulation of the human fc-neonatal receptor alpha-chain gene fcgrt by microrna-3181, Pharmaceutical Research, vol. 35, no. 1, 2018. https://doi.org/10.1007/s11095-017-2294-0[4] M. Yoshida, K. Kobayashi, T. Kuo, L. Bry, J. Glickman, S. Claypoolet al., Neonatal fc receptor for igg regulates mucosal immune responses to luminal bacteria, Journal of Clinical Investigation, vol. 116, no. 8, p. 2142-2151, 2006. https://doi.org/10.1172/jci27821[5] M. Pyzik, L. Kozicky, A. Gandhi, & R. Blumberg, The therapeutic age of the neonatal fc receptor, Nature Reviews Immunology, vol. 23, no. 7, p. 415-432, 2023. https://doi.org/10.1038/s41577-022-00821-1[6] J. Cervenak, B. Bender, Z. Schneider, M. Magna, B. Carstea, K. Liliomet al., Neonatal fcr overexpression boosts humoral immune response in transgenic mice, The Journal of Immunology, vol. 186, no. 2, p. 959-968, 2011. https://doi.org/10.4049/jimmunol.1000353
Recombinant human FCGRT is produced by expressing the expression vector that contains the human FCGRT gene segment (24-297aa) and the N-terminal GST-tag gene in E. coli. As confirmed by SDS-PAGE, this high-quality recombinant FCGRT protein achieves over 90% purity and is available in liquid or lyophilized powder forms. Ideal for studies in immunology, this recombinant FCGRT ensures reliable and consistent results for your research needs.
The human FCGRT protein is a critical component of the immune system, primarily involved in transporting and regulating immunoglobulin G (IgG) antibodies. It plays a pivotal role in the transcytosis of maternal IgG across the placenta, facilitating passive immunity from mother to fetus [3][4].
FCGRT operates through a pH-dependent mechanism, exhibiting a high affinity for IgG at acidic pH levels, such as those found in endosomes while releasing IgG at neutral pH, typical of the extracellular environment [3][5]. This property is essential for maintaining serum IgG levels and prolonging the half-life of IgG antibodies in circulation, which is crucial for effective immune responses [2][5]. Additionally, FCGRT is involved in recycling IgG and albumin, contributing to their homeostasis within the body [1][6].
References:[1] S. Reznik, A. Tiwari, & C. Ashby, Efgartigimod, an fcrn antagonist, as a potential treatment for post covid-19 syndrome, Acta Materia Medica, vol. 2, no. 2, 2023. https://doi.org/10.15212/amm-2023-0004[2] M. Babamohamadi, Anti-ctla-4 nanobody as a promising approach in cancer immunotherapy, Cell Death and Disease, vol. 15, no. 1, 2024. https://doi.org/10.1038/s41419-023-06391-x[3] D. Ferguson and J. Blanco, Regulation of the human fc-neonatal receptor alpha-chain gene fcgrt by microrna-3181, Pharmaceutical Research, vol. 35, no. 1, 2018. https://doi.org/10.1007/s11095-017-2294-0[4] M. Yoshida, K. Kobayashi, T. Kuo, L. Bry, J. Glickman, S. Claypoolet al., Neonatal fc receptor for igg regulates mucosal immune responses to luminal bacteria, Journal of Clinical Investigation, vol. 116, no. 8, p. 2142-2151, 2006. https://doi.org/10.1172/jci27821[5] M. Pyzik, L. Kozicky, A. Gandhi, & R. Blumberg, The therapeutic age of the neonatal fc receptor, Nature Reviews Immunology, vol. 23, no. 7, p. 415-432, 2023. https://doi.org/10.1038/s41577-022-00821-1[6] J. Cervenak, B. Bender, Z. Schneider, M. Magna, B. Carstea, K. Liliomet al., Neonatal fcr overexpression boosts humoral immune response in transgenic mice, The Journal of Immunology, vol. 186, no. 2, p. 959-968, 2011. https://doi.org/10.4049/jimmunol.1000353
| Cat.No | ACP02570 | Target Name | FCGRT |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | E.coli |
| Expression Range | 24-297aa | Mol Weight | 57.4kDa |
| Protein Length | Extracellular Domain | Purity | Greater than 90% as determined by SDS-PAGE. |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P55899 |
|---|
Uniprot Id
P55899
Target Species
Human
Target Name
FCGRT
Target Full Name
IgG receptor FcRn large subunit p51
Target Function
Cell surface receptor that transfers passive humoral immunity from the mother to the newborn. Binds to the Fc region of monomeric immunoglobulin gamma and mediates its selective uptake from milk. IgG in the milk is bound at the apical surface of the intestinal epithelium. The resultant FcRn-IgG complexes are transcytosed across the intestinal epithelium and IgG is released from FcRn into blood or tissue fluids. Throughout life, contributes to effective humoral immunity by recycling IgG and extending its half-life in the circulation. Mechanistically, monomeric IgG binding to FcRn in acidic endosomes of endothelial and hematopoietic cells recycles IgG to the cell surface where it is released into the circulation. In addition of IgG, regulates homeostasis of the other most abundant circulating protein albumin/ALB.; (Microbial infection) Acts as an uncoating receptor for a panel of echoviruses including Echovirus 5, 6, 7, 9, 11, 13, 25 and 29.
Target Subcellular Location
Cell membrane; Single-pass type I membrane protein. Endosome membrane.
Target Protein Families
Immunoglobulin superfamily
Target Tissue Specificity
Expressed in full-term placenta, heart, lung, liver, muscle, kidney, pancreas, and both fetal and adult small intestine.
Target Research Area
Immunology
Target Synonyms
Alpha chain; Fc fragment of IgG; receptor transporter; alpha; FCGRN_HUMAN; FCGRT; FcRn alpha chain; FcRn; FCRN; alpha chain; IgG Fc fragment receptor transporter alpha chain; IgG Gc receptor; IgG receptor FcRn large subunit p51; IgG receptor FcRn large subunit p51 precursor; Immunoglobulin receptor; intestinal; heavy chain; Neonatal Fc receptor
Target Background
This gene encodes a receptor that binds the Fc region of monomeric immunoglobulin G. The encoded protein transfers immunoglobulin G antibodies from mother to fetus across the placenta. This protein also binds immunoglobulin G to protect the antibody from degradation. Alternative splicing results in multiple transcript variants.
Free shipping on orders $999+
Advenit post multos Scudilo Scutariorum tribunus velament
We accept credit cards, PayPal, and bank wires
Responsive and knowledgable customer service via email, text or phone
Notification
