Recombinant Human Immunoglobulin-binding protein 1 (IGBP1)

Uniprot Id

P78318

Target Species

Human

Target Name

IGBP1

Target Full Name

Immunoglobulin-binding protein 1

Target Function

Associated to surface IgM-receptor; may be involved in signal transduction. Involved in regulation of the catalytic activity of the phosphatases PP2A, PP4 and PP6 by protecting their partially folded catalytic subunits from degradative polyubiquitination until they associate with regulatory subunits.

Target Involvement

Mental retardation, X-linked, syndromic, 28 (MRXS28)

Target Subcellular Location

Cytoplasm.

Target Protein Families

IGBP1/TAP42 family

Target Tissue Specificity

Ubiquitously expressed with highest levels in heart, skeletal muscle and pancreas.

Target Synonyms

Alpha 4; B cell signal transduction molecule alpha 4; B-cell signal transduction molecule alpha 4; bA351K23.1 (immunoglobulin binding protein 1 (CD79A) ); bA351K23.1; CD79a binding protein 1; CD79a-binding protein 1; IBP 1 ; IBP1; IGBP 1; Igbp1; IGBP1_HUMAN; Immunoglobulin (CD79A) binding protein 1; Immunoglobulin binding protein 1; Immunoglobulin-binding protein 1; Protein alpha 4; Protein alpha-4; Protein phosphatase 2/4/6 regulatory subunit; Protein phosphatase 2A regulatory subunit alpha 4; Renal carcinoma antigen NY REN 16; Renal carcinoma antigen NY-REN-16

Target Background

The proliferation and differentiation of B cells is dependent upon a B-cell antigen receptor (BCR) complex. Binding of antigens to specific B-cell receptors results in a tyrosine phosphorylation reaction through the BCR complex and leads to multiple signal transduction pathways.