Recombinant Human Importin subunit alpha-3 (KPNA3)

Uniprot Id

O00505

Target Species

Human

Target Name

KPNA3

Target Full Name

Importin subunit alpha-4

Target Function

Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. Recognizes NLSs of influenza A virus nucleoprotein probably through ARM repeats 7-9

Target Subcellular Location

Cytoplasm. Nucleus.

Target Protein Families

Importin alpha family

Target Tissue Specificity

Ubiquitous. Highest levels in heart and skeletal muscle.

Target Synonyms

SRP1 gamma; hSRP1; IMA4_HUMAN; Importin alpha 3; Importin alpha 3 subunit; Importin alpha 4; Importin alpha Q2; Importin subunit alpha-4; IPOA4; Karyopherin alpha 3; Karyopherin alpha 3 importin alpha 4; Karyopherin alpha 3 subunit; Karyopherin subunit alpha 3; Karyopherin subunit alpha-3; KPNA 3; Kpna3; Qip2; SRP1; SRP1-gamma; SRP1gamma; SRP4