Recombinant Human Inactive rhomboid protein 1 (RHBDF1), Truncated

Uniprot Id

Q96CC6

Target Species

Human

Target Name

RHBDF1

Target Full Name

Inactive rhomboid protein 1

Target Function

Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own.

Target Subcellular Location

Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.

Target Protein Families

Peptidase S54 family

Target Tissue Specificity

Highly expressed in cerebellum, cerebrum, heart, skeletal muscle, placenta, pancreatic islet and testis. Detected at lower levels in colon, kidney, small intestine and lung.

Target Synonyms

RHBDF1; C16orf8; DIST1; IRHOM1; Inactive rhomboid protein 1; iRhom1; Epidermal growth factor receptor-related protein; Rhomboid 5 homolog 1; Rhomboid family member 1; p100hRho

Target Background

Predicted to enable growth factor binding activity and serine-type endopeptidase activity. Involved in several processes, including negative regulation of protein secretion; regulation of epidermal growth factor receptor signaling pathway; and regulation of proteasomal protein catabolic process. Located in Golgi membrane and endoplasmic reticulum membrane.