Recombinant Human Inhibin beta B chain protein (INHBB), Truncated

Uniprot Id

P09529

Target Species

Human

Target Name

INHBB

Target Full Name

Inhibin beta B chain

Target Function

Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.

Target Subcellular Location

Secreted.

Target Protein Families

TGF-beta family

Target Research Area

Signal Transduction, Neuroscience

Target Synonyms

Activin beta B chain ; Activin beta-B chain; INHBB; INHBB_HUMAN; Inhibin beta 2; Inhibin beta B chain; Inhibin beta B subunit

Target Background

This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate a subunit of the dimeric activin and inhibin protein complexes. These complexes activate and inhibit, respectively, follicle stimulating hormone secretion from the pituitary gland. Polymorphisms near this gene are associated with pre-eclampsia in female human patients.