Recombinant Human Inhibitor of growth protein 5 (ING5)

Uniprot Id

Q8WYH8

Target Species

Human

Target Name

ING5

Target Full Name

Inhibitor of growth protein 5

Target Function

Component of the HBO1 complex, which specifically mediates acetylation of histone H3 at 'Lys-14' (H3K14ac) and, to a lower extent, acetylation of histone H4. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Through chromatin acetylation it may regulate DNA replication and may function as a transcriptional coactivator. Inhibits cell growth, induces a delay in S-phase progression and enhances Fas-induced apoptosis in an INCA1-dependent manner.

Target Subcellular Location

Nucleus. Chromosome.

Target Protein Families

ING family

Target Tissue Specificity

Down-regulated in bone marrow cells in acute myeloid leukemia patients as compared with normal bone marrow cells.

Target Synonyms

1700001C14Rik; 1700027H23Rik; 1810018M11Rik; FLJ23842; ING 5; Ing5; ING5_HUMAN; Inhibitor of growth family member 5; Inhibitor of growth protein 5; p28 ING 5; p28 ING5; p28ING5

Target Background

This gene encodes a tumor suppressor protein that inhibits cell growth and induces apoptosis. This protein contains a PHD-type zinc finger. It interacts with tumor suppressor p53 and p300, a component of the histone acetyl transferase complex, suggesting a role in transcriptional regulation. Alternative splicing and the use of multiple promoters and 3' terminal exons results in multiple transcript variants.