Recombinant Human Inositol-3-phosphate synthase 1 (ISYNA1)

Uniprot Id

Q9NPH2

Target Species

Human

Target Name

ISYNA1

Target Full Name

Inositol-3-phosphate synthase 1

Target Function

Key enzyme in myo-inositol biosynthesis pathway that catalyzes the conversion of glucose 6-phosphate to 1-myo-inositol 1-phosphate in a NAD-dependent manner. Rate-limiting enzyme in the synthesis of all inositol-containing compounds.

Target Subcellular Location

Cytoplasm.

Target Protein Families

Myo-inositol 1-phosphate synthase family

Target Tissue Specificity

Highly expressed in testis, ovary, heart, placenta and pancreas. Weakly expressed in blood leukocyte, thymus, skeletal muscle and colon.

Target Synonyms

hINO1; hIPS; INO1; INO1_HUMAN; INOS; Inositol 3 phosphate synthase 1; Inositol-3-phosphate synthase 1; IPS ; IPS 1; ISYNA 1; Isyna1; MI 1 P synthase; MI-1-P synthase; MI1P synthase; MIP synthase; Myo inositol 1 phosphate synthase A1; Myo-inositol 1-phosphate synthase A1; Myo-inositol-1-phosphate synthase

Target Background

This gene encodes an inositol-3-phosphate synthase enzyme. The encoded protein plays a critical role in the myo-inositol biosynthesis pathway by catalyzing the rate-limiting conversion of glucose 6-phosphate to myoinositol 1-phosphate. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 4.