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The expression vector recombined with the recombinant DNA was transformed into the E.coli for expression. The recombinant DNA resulted from the fusion of the gene coding for the 49-118aa of the human IGF1 protein and the N-terminal 6xHis tag gene. The product was purified and isolated to get the recombinant human IGF1 protein with N-terminal 6xHis tag. The purity of this recombinant IGF1 protein reaches up to 90%. Under SDS-PAGE condition, this recombinant IGF1 protein showed a band with a molecular weight of about 15 kDa on the gel. It may be used in the research of IGF1-participating signal transduction.IGF-1 is a gene encoding a protein named insulin-like growth factor I (abbreviated IGF1) and belongs to insulin family, which are structurally closely related to pro-insulin. IGF-1 can bind to and activate insulin receptors. The peptide family has two members, IGF-1, the adult form, and IGF-2, the major fetal form. The human IGF-1 gene consists of six exons, including two leader exons, and has two promoters. IGF1 is the major mediator of prenatal and postnatal growth. The disease involved IGF1 is called insulin-like growth factor I deficiency (IGF1 deficiency). IGF1 is produced primarily in liver and serves as an endocrine hormone mediating the action of GH in peripheral tissues such as muscle, cartilage, bone, kidney, nerves, skin, lungs, and the liver itself.
The expression vector recombined with the recombinant DNA was transformed into the E.coli for expression. The recombinant DNA resulted from the fusion of the gene coding for the 49-118aa of the human IGF1 protein and the N-terminal 6xHis tag gene. The product was purified and isolated to get the recombinant human IGF1 protein with N-terminal 6xHis tag. The purity of this recombinant IGF1 protein reaches up to 90%. Under SDS-PAGE condition, this recombinant IGF1 protein showed a band with a molecular weight of about 15 kDa on the gel. It may be used in the research of IGF1-participating signal transduction.IGF-1 is a gene encoding a protein named insulin-like growth factor I (abbreviated IGF1) and belongs to insulin family, which are structurally closely related to pro-insulin. IGF-1 can bind to and activate insulin receptors. The peptide family has two members, IGF-1, the adult form, and IGF-2, the major fetal form. The human IGF-1 gene consists of six exons, including two leader exons, and has two promoters. IGF1 is the major mediator of prenatal and postnatal growth. The disease involved IGF1 is called insulin-like growth factor I deficiency (IGF1 deficiency). IGF1 is produced primarily in liver and serves as an endocrine hormone mediating the action of GH in peripheral tissues such as muscle, cartilage, bone, kidney, nerves, skin, lungs, and the liver itself.
| Cat.No | ACP02399 | Target Name | IGF1 |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | E.coli |
| Expression Range | 49-118aa | Mol Weight | 13.2 kDa |
| Protein Length | Full Length of Mature Protein | Purity | Greater than 90% as determined by SDS-PAGE. |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P05019 |
|---|
Uniprot Id
P05019
Target Species
Human
Target Name
IGF1
Target Full Name
Insulin-like growth factor 1
Target Function
The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exocytosis of IGF1 is required for sensory perception of smell in the olfactory bulb. Acts as a ligand for IGF1R. Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiatiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways. Binds to integrins ITGAV:ITGB3 and ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and IGFR1 are essential for IGF1 signaling. Induces the phosphorylation and activation of IGFR1, MAPK3/ERK1, MAPK1/ERK2 and AKT1.
Target Involvement
Insulin-like growth factor I deficiency (IGF1 deficiency)
Target Subcellular Location
Secreted.
Target Protein Families
Insulin family
Target Research Area
Signal Transduction
Target Synonyms
IBP1; IGF I; IGF IA; IGF IB; IGF-I; Igf1; IGF1_HUMAN; IGF1A; IGFI; IGFIA; Insulin like growth factor 1 (somatomedin C) ; Insulin like growth factor 1; Insulin like growth factor IA; Insulin like growth factor IB; Insulin-like growth factor I; Mechano growth factor; MGF; OTTHUMP00000195080; OTTHUMP00000195081; OTTHUMP00000195082; OTTHUMP00000195083; OTTHUMP00000195084; Somatomedia C; Somatomedin C; Somatomedin-C
Target Background
The protein encoded by this gene is similar to insulin in function and structure and is a member of a family of proteins involved in mediating growth and development. The encoded protein is processed from a precursor, bound by a specific receptor, and secreted. Defects in this gene are a cause of insulin-like growth factor I deficiency. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein.
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