Recombinant Human Insulin receptor substrate 4 (IRS4), Truncated

Uniprot Id

O14654

Target Species

Human

Target Name

IRS4

Target Full Name

Insulin receptor substrate 4

Target Function

Acts as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such as insulin receptor, IGF1R and FGFR1, and a complex network of intracellular signaling molecules containing SH2 domains. Involved in the IGF1R mitogenic signaling pathway. Promotes the AKT1 signaling pathway and BAD phosphorylation during insulin stimulation without activation of RPS6KB1 or the inhibition of apoptosis. Interaction with GRB2 enhances insulin-stimulated mitogen-activated protein kinase activity. May be involved in nonreceptor tyrosine kinase signaling in myoblasts. Plays a pivotal role in the proliferation/differentiation of hepatoblastoma cell through EPHB2 activation upon IGF1 stimulation. May play a role in the signal transduction in response to insulin and to a lesser extent in response to IL4 and GH on mitogenesis. Plays a role in growth, reproduction and glucose homeostasis. May act as negative regulators of the IGF1 signaling pathway by suppressing the function of IRS1 and IRS2.

Target Subcellular Location

Cell membrane; Peripheral membrane protein; Cytoplasmic side.

Target Tissue Specificity

Expressed in myoblasts. Expressed in liver and hepatocellular carcinoma.

Target Synonyms

IRS4; Insulin receptor substrate 4; IRS-4; 160 kDa phosphotyrosine protein; py160; Phosphoprotein of 160 kDa; pp160