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| Cat.No | ACP08468 | Target Name | ITM2C |
|---|---|---|---|
| Target Synonyms | ITM2C; BRI3; hucep-14; NPD018; PSEC0047; Integral membrane protein 2C; Cerebral protein 14; Transmembrane protein BRI3 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Protein Length | Partial |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q9NQX7 |
|---|
Uniprot Id
Q9NQX7
Target Species
Human
Target Name
ITM2C
Target Full Name
Integral membrane protein 2C
Target Function
Negative regulator of amyloid-beta peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation.
Target Subcellular Location
Lysosome membrane; Single-pass type II membrane protein. Cell membrane; Single-pass type II membrane protein.
Target Protein Families
ITM2 family
Target Tissue Specificity
High levels in the brain, specifically in the cerebral cortex, medulla, amygdala, hippocampus, thalamus, caudate nucleus, cerebellum, olfactory lobe and spinal cord. Very low levels in other organs.
Target Synonyms
ITM2C; BRI3; hucep-14; NPD018; PSEC0047; Integral membrane protein 2C; Cerebral protein 14; Transmembrane protein BRI3
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