Recombinant Human Integrin alpha-6 (ITGA6), Truncated

Cat.No	ACP23381	Target Name	ITGA6
Target Synonyms	alpha 6; ITA6_HUMAN; ITGA6; ITGA6B; Processed integrin alpha-6; VLA 6; VLA-6, Alpha6p; CD49 antigen-like family member F; CD49f; Integrin alpha6B; Integrin	Form	Lyophilized powder
Expression System	Custom Production. Please inquire and provide the desire expression system.	Protein Length	Partial
Purity	>85% (SDS-PAGE)	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP23381

Target Name

ITGA6

Target Synonyms

alpha 6; ITA6_HUMAN; ITGA6; ITGA6B; Processed integrin alpha-6; VLA 6; VLA-6, Alpha6p; CD49 antigen-like family member F; CD49f; Integrin alpha6B; Integrin

Form

Lyophilized powder

Expression System

Custom Production. Please inquire and provide the desire expression system.

Protein Length

Partial

Purity

>85% (SDS-PAGE)

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	P23229

Background Information

Uniprot Id

P23229
Target Species

Human
Target Name

ITGA6
Target Full Name

Integrin alpha-6
Target Function

Integrin alpha-6/beta-1 (ITGA6:ITGB1) is a receptor for laminin on platelets. Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion. Integrin alpha-6/beta-4 (ITGA6:ITGB4) is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling. ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling. ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling.
Target Involvement

Epidermolysis bullosa letalis, with pyloric atresia (EB-PA)
Target Subcellular Location

Cell membrane; Single-pass type I membrane protein. Cell membrane; Lipid-anchor.
Target Protein Families

Integrin alpha chain family
Target Tissue Specificity

Integrin alpha-6/beta-4 is predominantly expressed by epithelia. Isoforms containing segment X1 are ubiquitously expressed. Isoforms containing segment X1X2 are expressed in heart, kidney, placenta, colon, duodenum, myoblasts and myotubes, and in a limite
Target Synonyms

Alpha6p; CD49 antigen-like family member F; CD49f; Integrin alpha6B; Integrin, alpha 6; ITA6_HUMAN; ITGA6; ITGA6B; Processed integrin alpha-6; VLA 6; VLA-6
Target Background

The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 6 subunit. This subunit may associate with a beta 1 or beta 4 subunit to form an integrin that interacts with extracellular matrix proteins including members of the laminin family. The alpha 6 beta 4 integrin may promote tumorigenesis, while the alpha 6 beta 1 integrin may negatively regulate erbB2/HER2 signaling. Alternative splicing results in multiple transcript variants.

Recombinant Human Integrin alpha-6 (ITGA6), Truncated

Specifications

Immunogen Information

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