Recombinant Human Integrin alpha-9 (ITGA9), Truncated

Uniprot Id

Q13797

Target Species

Human

Target Name

ITGA9

Target Full Name

Integrin alpha-9

Target Function

Integrin alpha-9/beta-1 (ITGA9:ITGB1) is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin.

Target Subcellular Location

Membrane; Single-pass type I membrane protein.

Target Protein Families

Integrin alpha chain family

Target Tissue Specificity

In airway epithelium, in the basal layer of squamous epithelium, and in smooth muscle, skeletal muscle, and hepatocytes. Abundantly expressed in fetal lung and lung cancers.

Target Synonyms

Alpha RLC; Integrin alpha 4 like ; Integrin alpha RLC; Integrin alpha-9; Integrin alpha-RLC; ITA9_HUMAN; ITGA 4L; ITGA 9; ITGA4L ; ITGA9; RLC

Target Background

This gene encodes an alpha integrin. Integrins are heterodimeric integral membrane glycoproteins composed of an alpha chain and a beta chain that mediate cell-cell and cell-matrix adhesion. The protein encoded by this gene, when bound to the beta 1 chain, forms an integrin that is a receptor for VCAM1, cytotactin and osteopontin. Expression of this gene has been found to be upregulated in small cell lung cancers.