Recombinant Human Integrin alpha-L (ITGAL), Truncated

Cat.No	ACP00592	Target Name	ITGAL
Target Synonyms	CD11 antigen-like family member A;Leukocyte adhesion glycoprotein LFA-1 alpha chain;LFA-1A;Leukocyte function-associated molecule 1 alpha chain;CD antigen CD11a	Form	Liquid or Lyophilized powder
Expression System	Mammalian cell	Expression Range	150-336aa
Mol Weight	50.2 kDa	Protein Length	Partial
Purity	Greater than 95% as determined by SDS-PAGE.Greater than 90% as determined by SEC-HPLC.	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP00592

Target Name

ITGAL

Target Synonyms

CD11 antigen-like family member A;Leukocyte adhesion glycoprotein LFA-1 alpha chain;LFA-1A;Leukocyte function-associated molecule 1 alpha chain;CD antigen CD11a

Form

Liquid or Lyophilized powder

Expression System

Mammalian cell

Expression Range

150-336aa

Mol Weight

50.2 kDa

Protein Length

Partial

Purity

Greater than 95% as determined by SDS-PAGE.Greater than 90% as determined by SEC-HPLC.

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	P20701

Background Information

Uniprot Id

P20701
Target Species

Human
Target Name

ITGAL
Target Full Name

Integrin alpha-L
Target Function

Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is a receptor for F11R. Integin ITGAL/ITGB2 is a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL. Involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes. Contributes to natural killer cell cytotoxicity. Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils. Required for generation of common lymphoid progenitor cells in bone marrow, indicating a role in lymphopoiesis. Integrin ITGAL/ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages.
Target Subcellular Location

Cell membrane; Single-pass type I membrane protein.
Target Protein Families

Integrin alpha chain family
Target Tissue Specificity

Leukocytes.
Target Research Area

Immunology
Target Synonyms

Antigen CD11A (p180); lymphocyte function associated antigen 1; alpha polypeptide; CD11 antigen-like family member A; CD11a; CD18; CR3; Integrin alpha-L; Integrin beta 2 ; Integrin gene promoter; ITAL_HUMAN; Itgal; ITGAM; ITGB2; LAD; Leukocyte adhesion glycoprotein LFA-1 alpha chain; Leukocyte function-associated molecule 1 alpha chain; LFA 1 alpha; LFA 1; LFA-1A; LFA1; LFA1A; Lymphocyte function associated antigen 1; MAC1; MFI7; MO1A
Target Background

ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling. Two transcript variants encoding different isoforms have been found for this gene.

Recombinant Human Integrin alpha-L (ITGAL), Truncated

Specifications

Immunogen Information

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