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In the production of the recombinant Human ITGB7 protein in e.coli cells, a sequential pipeline involves constructing the expression vector coding for the Human ITGB7 protein (20-723aa), transforming the recombinant vector into e.coli cells, selecting the positive cells and cultivating them, lysing cells, and characterizing the protein. The resulting recombinant Human ITGB7 protein is purified from the cell lysate using affinity purification. Its purity exceeds 85%, as determined by SDS-PAGE.
In the production of the recombinant Human ITGB7 protein in e.coli cells, a sequential pipeline involves constructing the expression vector coding for the Human ITGB7 protein (20-723aa), transforming the recombinant vector into e.coli cells, selecting the positive cells and cultivating them, lysing cells, and characterizing the protein. The resulting recombinant Human ITGB7 protein is purified from the cell lysate using affinity purification. Its purity exceeds 85%, as determined by SDS-PAGE.
| Cat.No | ACP02054 | Target Name | ITGB7 |
|---|---|---|---|
| Target Synonyms | ITGB7; Integrin beta-7; Gut homing receptor beta subunit | Form | Liquid or Lyophilized powder |
| Expression System | E.coli | Expression Range | 20-723aa |
| Mol Weight | 82.5 kDa | Protein Length | Partial |
| Purity | Greater than 85% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P26010 |
|---|
Uniprot Id
P26010
Target Species
Human
Target Name
ITGB7
Target Full Name
Integrin beta-7
Target Function
Integrin alpha-4/beta-7 (Peyer patches-specific homing receptor LPAM-1) is an adhesion molecule that mediates lymphocyte migration and homing to gut-associated lymphoid tissue (GALT). Integrin alpha-4/beta-7 interacts with the cell surface adhesion molecules MADCAM1 which is normally expressed by the vascular endothelium of the gastrointestinal tract. Interacts also with VCAM1 and fibronectin, an extracellular matrix component. It recognizes one or more domains within the alternatively spliced CS-1 region of fibronectin. Interactions involves the tripeptide L-D-T in MADCAM1, and L-D-V in fibronectin. Binds to HIV-1 gp120, thereby allowing the virus to enter GALT, which is thought to be the major trigger of AIDS disease. Interaction would involve a tripeptide L-D-I in HIV-1 gp120. Integrin alpha-E/beta-7 (HML-1) is a receptor for E-cadherin.
Target Subcellular Location
Membrane; Single-pass type I membrane protein.
Target Protein Families
Integrin beta chain family
Target Tissue Specificity
Expressed in a variety of leukocyte lines.
Target Research Area
Signal Transduction
Target Synonyms
ITGB7; Integrin beta-7; Gut homing receptor beta subunit
Target Background
This gene encodes a protein that is a member of the integrin superfamily. Members of this family are adhesion receptors that function in signaling from the extracellular matrix to the cell. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The encoded protein forms dimers with an alpha4 chain or an alphaE chain and plays a role in leukocyte adhesion. Dimerization with alpha4 forms a homing receptor for migration of lymphocytes to the intestinal mucosa and Peyer's patches. Dimerization with alphaE permits binding to the ligand epithelial cadherin, a calcium-dependent adhesion molecule. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.
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