Recombinant Human Intercellular adhesion molecule 2 (ICAM2), Truncated

Uniprot Id

P13598

Target Species

Human

Target Name

ICAM2

Target Full Name

Intercellular adhesion molecule 2

Target Function

ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM2 may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance.

Target Subcellular Location

Membrane; Single-pass type I membrane protein. Cell projection, microvillus.

Target Protein Families

Immunoglobulin superfamily, ICAM family

Target Synonyms

ICAM2; Intercellular adhesion molecule 2; ICAM-2; CD antigen CD102

Target Background

The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance. Several transcript variants encoding the same protein have been found for this gene.