Recombinant Human Intercellular adhesion molecule 5 (ICAM5), Truncated

Uniprot Id

Q9UMF0

Target Species

Human

Target Name

ICAM5

Target Full Name

Intercellular adhesion molecule 5

Target Function

ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2).

Target Subcellular Location

Membrane; Single-pass type I membrane protein.

Target Protein Families

Immunoglobulin superfamily, ICAM family

Target Tissue Specificity

Expressed on neurons in the most rostral segment of the mammalian brain, the telencephalon.

Target Synonyms

ICAM5; TLCN; TLNIntercellular adhesion molecule 5; ICAM-5; Telencephalin

Target Background

The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is expressed on the surface of telencephalic neurons and displays two types of adhesion activity, homophilic binding between neurons and heterophilic binding between neurons and leukocytes. It may be a critical component in neuron-microglial cell interactions in the course of normal development or as part of neurodegenerative diseases.