Recombinant Human Interferon-induced protein with tetratricopeptide repeats 5 (IFIT5)

Uniprot Id

Q13325

Target Species

Human

Target Name

IFIT5

Target Full Name

Interferon-induced protein with tetratricopeptide repeats 5

Target Function

Interferon-induced RNA-binding protein involved in the human innate immune response. Has a broad and adaptable RNA structure recognition important for RNA recognition specificity in antiviral defense. Binds precursor and processed tRNAs as well as poly-U-tailed tRNA fragments. Specifically binds single-stranded RNA bearing a 5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs. Single-stranded PPP-RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-sequence-specific manner. Also recognizes and selectively binds AT-rich dsDNA. Additionally, as a mediator in innate immunity, regulates positively IKK-NFKB signaling by sinergizing the recruitment of IKK to MAP3K7.

Target Subcellular Location

Cell projection, ruffle membrane. Note=Colocalized with DDX58/RIG-I at cell surface ruffles. Localizes to actin-rich protrusions from the apical cell surface.

Target Protein Families

IFIT family

Target Synonyms

FLJ53857; FLJ92678; IFIT-5; IFIT5; IFIT5_HUMAN; Interferon induced protein with tetratricopeptide repeats 5; Interferon-induced protein with tetratricopeptide repeats 5; Retinoic acid and interferon inducible 58 kDa protein ; Retinoic acid and interferon inducible protein (58kD); Retinoic acid- and interferon-inducible 58 kDa protein; RI58