Recombinant Human Interleukin-1 receptor accessory protein-like 1 (IL1RAPL1), Truncated

Uniprot Id

Q9NZN1

Target Species

Human

Target Name

IL1RAPL1

Target Full Name

Interleukin-1 receptor accessory protein-like 1

Target Function

May regulate secretion and presynaptic differentiation through inhibition of the activity of N-type voltage-gated calcium channel. May activate the MAP kinase JNK. Plays a role in neurite outgrowth. During dendritic spine formation can bidirectionally induce pre- and post-synaptic differentiation of neurons by trans-synaptically binding to PTPRD.

Target Involvement

Mental retardation, X-linked 21 (MRX21)

Target Subcellular Location

Cell membrane; Single-pass type I membrane protein. Cytoplasm. Cell projection, axon. Cell projection, dendrite.

Target Protein Families

Interleukin-1 receptor family

Target Tissue Specificity

Detected at low levels in heart, skeletal muscle, ovary, skin, amygdala, caudate nucleus, corpus callosum, hippocampus, substantia nigra and thalamus. Detected at very low levels in tonsil, prostate, testis, small intestine, placenta, colon and fetal live

Target Synonyms

IL 1 RAPL 1; IL 1RAPL 1; IL-1-RAPL-1; IL-1RAPL-1; IL1R8; IL1RAPL 1; IL1RAPL; IL1RAPL-1; IL1RAPL1; Interleukin 1 receptor 8; Interleukin 1 receptor accessory protein like 1; Interleukin-1 receptor accessory protein-like 1; IRPL1_HUMAN; Mental retardation X linked 10; Mental retardation X linked 21; Mental retardation X linked 34; MRX 21; MRX 34; MRX10; MRX21; MRX34; Oligophrenin 4; Oligophrenin-4; Oligophrenin4; OPHN 4; OPHN4; Three immunoglobulin domain containing IL 1 receptor related 2; Three immunoglobulin domain-containing IL-1 receptor-related 2; TIGIRR 2; TIGIRR-2; TIGIRR2; X linked interleukin 1 receptor accessory protein like 1; X-linked interleukin-1 receptor accessory protein-like 1

Target Background

The protein encoded by this gene is a member of the interleukin 1 receptor family and is similar to the interleukin 1 accessory proteins. This protein has an N-terminal signal peptide, three extracellular immunoglobulin Ig-like domains, a transmembrane domain, an intracellular Toll/IL-1R domain, and a long C-terminal tail which interacts with multiple signalling molecules. This gene is located at a region on chromosome X that is associated with a non-syndromic form of X-linked intellectual disability. Deletions and mutations in this gene were found in patients with intellectual disability. This gene is expressed at a high level in post-natal brain structures involved in the hippocampal memory system, which suggests a specialized role in the physiological processes underlying memory and learning abilities, and plays a role in synapse formation and stabilization.