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Advance your immunology research with the high-quality Recombinant Human IL2 protein, a crucial cytokine known for its pivotal role in T-cell activation, differentiation, and proliferation. IL2 has been extensively studied for its involvement in the immune system, particularly in modulating the balance between effector and regulatory T-cells, which is vital for a healthy immune response. Our Recombinant Human IL2 protein features the full length of the mature protein (21-153 amino acids) to ensure optimal bioactivity and functionality. Expressed in yeast, this protein is equipped with an N-terminal 6xHis-tag for easy purification and detection without affecting the native structure or biological activity of the protein. With a purity of greater than 90% as determined by SDS-PAGE, our Recombinant Human IL2 protein delivers consistent and reliable results, supporting your research efforts with confidence. Select from liquid or lyophilized powder forms to suit your experimental needs.
Advance your immunology research with the high-quality Recombinant Human IL2 protein, a crucial cytokine known for its pivotal role in T-cell activation, differentiation, and proliferation. IL2 has been extensively studied for its involvement in the immune system, particularly in modulating the balance between effector and regulatory T-cells, which is vital for a healthy immune response.
Our Recombinant Human IL2 protein features the full length of the mature protein (21-153 amino acids) to ensure optimal bioactivity and functionality. Expressed in yeast, this protein is equipped with an N-terminal 6xHis-tag for easy purification and detection without affecting the native structure or biological activity of the protein. With a purity of greater than 90% as determined by SDS-PAGE, our Recombinant Human IL2 protein delivers consistent and reliable results, supporting your research efforts with confidence. Select from liquid or lyophilized powder forms to suit your experimental needs.
| Cat.No | ACP02465 | Target Name | IL2 |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | Yeast |
| Expression Range | 21-153aa | Mol Weight | 17.4kDa |
| Protein Length | Full Length of Mature Protein | Purity | Greater than 90% as determined by SDS-PAGE. |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P60568 |
|---|
Uniprot Id
P60568
Target Species
Human
Target Name
IL2
Target Full Name
Interleukin-2
Target Function
Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.
Target Involvement
A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17.
Target Subcellular Location
Secreted.
Target Protein Families
IL-2 family
Target Research Area
Immunology
Target Synonyms
Aldesleukin; IL 2; IL-2; IL2; IL2_HUMAN; Interleukin 2; Interleukin-2; interleukin2; Involved in regulation of T cell clonal expansion; Lymphokine; OTTHUMP00000164090; POIL2; T Cell Growth Factor; T-cell growth factor; TCGF
Target Background
This gene is a member of the interleukin 2 (IL2) cytokine subfamily which includes IL4, IL7, IL9, IL15, IL21, erythropoietin, and thrombopoietin. The protein encoded by this gene is a secreted cytokine produced by activated CD4+ and CD8+ T lymphocytes, that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine (IL2R) is a heterotrimeric protein complex whose gamma chain is also shared by IL4 and IL7. The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli.
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