Recombinant Human Interleukin-21 (IL21), Truncated

Uniprot Id

Q9HBE4

Target Species

Human

Target Name

IL21

Target Full Name

Interleukin-21

Target Function

Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells. Implicated in the generation and maintenance of T follicular helper (Tfh) cells and the formation of germinal-centers. Together with IL6, control the early generation of Tfh cells and are critical for an effective antibody response to acute viral infection. May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation.

Target Involvement

Immunodeficiency, common variable, 11 (CVID11)

Target Subcellular Location

Secreted.

Target Protein Families

IL-15/IL-21 family

Target Tissue Specificity

Expressed in activated CD4-positive T-cells but not in CD8-positive T-cells, B-cells, or monocytes.

Target Research Area

Immunology

Target Synonyms

CVID11; IL 21; IL-21; Il21; IL21_HUMAN; Interleukin 21; Interleukin-21; interleukin-21 isoform; Interleukin21; OTTHUMP00000164088; Za11

Target Background

This gene encodes a member of the common-gamma chain family of cytokines with immunoregulatory activity. The encoded protein plays a role in both the innate and adaptive immune responses by inducing the differentiation, proliferation and activity of multiple target cells including macrophages, natural killer cells, B cells and cytotoxic T cells. Dysregulation of this gene plays a role in multiple immune-mediated diseases including lupus, psoriasis and chronic inflammatory diseases. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.