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Recombinant Human Interleukin-31 (IL31)

ACP05071

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Specifications

Cat.No	ACP05071	Target Name	IL31
Target Synonyms	IL 31; IL-31; IL31; IL31_HUMAN; Interleukin 31; Interleukin-31	Form	Liquid or Lyophilized powder
Expression System	E.coli	Expression Range	24-164aa
Mol Weight	20.6 kDa	Protein Length	Full Length of Mature Protein
Purity	Greater than 85% as determined by SDS-PAGE.	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information

Target Species	Human	Uniprot ID	Q6EBC2

Background Information

Uniprot Id

Q6EBC2
Target Species

Human
Target Name

IL31
Target Full Name

Interleukin-31
Target Function

Activates STAT3 and possibly STAT1 and STAT5 through the IL31 heterodimeric receptor composed of IL31RA and OSMR. May function in skin immunity. Enhances myeloid progenitor cell survival in vitro. Induces RETNLA and serum amyloid A protein expression in macrophages.
Target Subcellular Location

Secreted.
Target Tissue Specificity

Detected at low levels in testis, bone marrow, skeletal muscle, kidney, colon, thymus, small intestine and trachea.
Target Research Area

Immunology
Target Synonyms

IL 31; IL-31; IL31; IL31_HUMAN; Interleukin 31; Interleukin-31
Target Background

IL31, which is made principally by activated Th2-type T cells, interacts with a heterodimeric receptor consisting of IL31RA (MIM 609510) and OSMR (MIM 601743) that is constitutively expressed on epithelial cells and keratinocytes. IL31 may be involved in the promotion of allergic skin disorders and in regulating other allergic diseases, such as asthma (Dillon et al., 2004 [PubMed 15184896]).

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Recombinant Human Interleukin-31 (IL31)

Specifications

Immunogen Information

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