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| Cat.No | ACP18790 | Target Name | IFFO1 |
|---|---|---|---|
| Target Synonyms | IFFO1; IFFOIntermediate filament family orphan 1; Tumor antigen HOM-TES-103 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 1-559 |
| Protein Length | Full length protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q0D2I5 |
|---|
Uniprot Id
Q0D2I5
Target Species
Human
Target Name
IFFO1
Target Full Name
Non-homologous end joining factor IFFO1
Target Function
Nuclear matrix protein involved in the immobilization of broken DNA ends and the suppression of chromosome translocation during DNA double-strand breaks (DSBs). Interacts with the nuclear lamina component LMNA, resulting in the formation of a nucleoskeleton that relocalizes to the DSB sites in a XRCC4-dependent manner and promotes the immobilization of the broken ends, thereby preventing chromosome translocation. Acts as a scaffold that allows the DNA repair protein XRCC4 and LMNA to assemble into a complex at the DSB sites.
Target Subcellular Location
Nucleus. Nucleus, nucleoplasm. Nucleus inner membrane. Nucleus matrix.
Target Protein Families
Intermediate filament family
Target Tissue Specificity
Ubiquitously expressed.
Target Synonyms
IFFO1; IFFOIntermediate filament family orphan 1; Tumor antigen HOM-TES-103
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