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| Cat.No | ACP13083 | Target Name | JMY |
|---|---|---|---|
| Form | Lyophilized powder | Expression System | Custom Production. Please inquire and provide the desire expression system. |
| Protein Length | Partial | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q8N9B5 |
|---|
Uniprot Id
Q8N9B5
Target Species
Human
Target Name
JMY
Target Full Name
Junction-mediating and -regulatory protein
Target Function
Acts both as a nuclear p53/TP53-cofactor and a cytoplasmic regulator of actin dynamics depending on conditions. In nucleus, acts as a cofactor that increases p53/TP53 response via its interaction with p300/EP300. Increases p53/TP53-dependent transcription and apoptosis, suggesting an important role in p53/TP53 stress response such as DNA damage. In cytoplasm, acts as a nucleation-promoting factor for both branched and unbranched actin filaments. Activates the Arp2/3 complex to induce branched actin filament networks. Also catalyzes actin polymerization in the absence of Arp2/3, creating unbranched filaments. Contributes to cell motility by controlling actin dynamics. May promote the rapid formation of a branched actin network by first nucleating new mother filaments and then activating Arp2/3 to branch off these filaments. The p53/TP53-cofactor and actin activator activities are regulated via its subcellular location.
Target Subcellular Location
Nucleus. Cytoplasm, cytoskeleton.
Target Protein Families
JMY family
Target Synonyms
FLJ37870; Jmy; JMY protein; JMY_HUMAN; junction mediating and regulatory protein ; Junction mediating and regulatory protein p53 cofactor; Junction-mediating and -regulatory protein; MGC163496 ; OTTHUMP00000161976; WAS protein homology region 2 domain containing 1-like 3; WHDC1L3
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