Recombinant Human Junctional adhesion molecule-like (AMICA1), Truncated

Cat.No	ACP15388	Target Name	JAML
Form	Lyophilized powder	Expression System	Custom Production. Please inquire and provide the desire expression system.
Protein Length	Partial	Purity	>85% (SDS-PAGE)
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP15388

Target Name

JAML

Form

Lyophilized powder

Expression System

Custom Production. Please inquire and provide the desire expression system.

Protein Length

Partial

Purity

>85% (SDS-PAGE)

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	Q86YT9

Background Information

Uniprot Id

Q86YT9
Target Species

Human
Target Name

JAML
Target Full Name

Junctional adhesion molecule-like
Target Function

Transmembrane protein of the plasma membrane of leukocytes that control their migration and activation through interaction with CXADR, a plasma membrane receptor found on adjacent epithelial and endothelial cells. The interaction between both receptors mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. It also controls the transmigration of leukocytes within epithelial and endothelial tissues through adhesive interactions with epithelial and endothelial CXADR.
Target Subcellular Location

Cell membrane; Single-pass type I membrane protein. Cell junction. Note=Localized at the plasma membrane and enriched in areas of cell-cell contacts (PubMed:12869515).
Target Protein Families

Immunoglobulin superfamily
Target Tissue Specificity

Expression is restricted to the hematopoietic tissues with the exception of liver. Expressed in fetal liver, spleen and thymus. Preferentially expressed by mature leukocytes (at protein level).
Target Synonyms

adhesion molecule AMICA; Adhesion molecule interacting with CXADR antigen 1; adhesion molecule interacts with CXADR antigen 1; adhesion molecule that interacts with CXADR antigen 1; AMICA; Amica1; CREA7-1; CREA7-4; Dendritic cell-specific protein CREA7-1; dendritic-cell specific protein CREA7-1; dendritic-cell specific protein CREA7-4; FLJ37080; Gm638; JAML1_HUMAN; junctional adhesion molecule; Junctional adhesion molecule-like; Junctional adhesion molecule-like precursor; MGC118814; MGC118815; UNQ722/PRO1387

Recombinant Human Junctional adhesion molecule-like (AMICA1), Truncated

Specifications

Immunogen Information

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