Home Products Recombinant Human Kelch-like protein 24 (KLHL24)

Recombinant Human Kelch-like protein 24 (KLHL24)

ACP16218

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Specifications

Cat.No	ACP16218	Target Name	KLHL24
Target Synonyms	KLHL24; DRE1; Kelch-like protein 24; Kainate receptor-interacting protein for GluR6; KRIP6; Protein DRE1	Form	Lyophilized powder
Expression System	Custom Production. Please inquire and provide the desire expression system.	Expression Range	1-600
Protein Length	Full length protein	Purity	>85% (SDS-PAGE)
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information

Target Species	Human	Uniprot ID	Q6TFL4

Background Information

Uniprot Id

Q6TFL4
Target Species

Human
Target Name

KLHL24
Target Full Name

Kelch-like protein 24
Target Function

Necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. As part of the BCR(KLHL24) E3 ubiquitin ligase complex, mediates ubiquitination of KRT14 and controls its levels during keratinocytes differentiation. Specifically reduces kainate receptor-mediated currents in hippocampal neurons, most probably by modulating channel properties.
Target Involvement

Epidermolysis bullosa simplex, generalized, with scarring and hair loss (EBSSH)
Target Subcellular Location

Perikaryon. Cell projection, axon. Cytoplasm. Cell junction, desmosome. Cell junction, adherens junction.
Target Tissue Specificity

Expressed in the skin. Found in keratinocytes, dermal fibroblasts, and melanocytes. Basal-layer keratinocytes have lower KLHL24 expression than suprabasal keratinocytes.
Target Synonyms

KLHL24; DRE1; Kelch-like protein 24; Kainate receptor-interacting protein for GluR6; KRIP6; Protein DRE1

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Recombinant Human Kelch-like protein 24 (KLHL24)

Specifications

Immunogen Information

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