Recombinant Human Keratin, type II cytoskeletal 2 epidermal (KRT2)

Uniprot Id

P35908

Target Species

Human

Target Name

KRT2

Target Full Name

Keratin, type II cytoskeletal 2 epidermal

Target Function

Probably contributes to terminal cornification. Associated with keratinocyte activation, proliferation and keratinization. Plays a role in the establishment of the epidermal barrier on plantar skin.

Target Involvement

Ichthyosis bullosa of Siemens (IBS)

Target Protein Families

Intermediate filament family

Target Tissue Specificity

Expressed in the upper spinous and granular suprabasal layers of normal adult epidermal tissues from most body sites including thigh, breast nipple, foot sole, penile shaft and axilla. Not present in foreskin, squamous metaplasias and carcinomas. Expressi

Target Research Area

Others

Target Synonyms

KRT2; KRT2A; KRT2E; Keratin; type II cytoskeletal 2 epidermal; Cytokeratin-2e; CK-2e; Epithelial keratin-2e; Keratin-2 epidermis; Keratin-2e; K2e; Type-II keratin Kb2

Target Background

The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is expressed largely in the upper spinous layer of epidermal keratinocytes and mutations in this gene have been associated with bullous congenital ichthyosiform erythroderma. The type II cytokeratins are clustered in a region of chromosome 12q12-q13.