Recombinant Human Ketosamine-3-kinase (FN3KRP)

Uniprot Id

Q9HA64

Target Species

Human

Target Name

FN3KRP

Target Full Name

Ketosamine-3-kinase

Target Function

Ketosamine-3-kinase involved in protein deglycation by mediating phosphorylation of ribuloselysine and psicoselysine on glycated proteins, to generate ribuloselysine-3 phosphate and psicoselysine-3 phosphate, respectively. Ribuloselysine-3 phosphate and psicoselysine-3 phosphate adducts are unstable and decompose under physiological conditions. Not able to phosphorylate fructoselysine.

Target Protein Families

Fructosamine kinase family

Target Tissue Specificity

Widely expressed; except in skeletal muscle where it is expressed at very low level. Expressed in erythrocytes.

Target Synonyms

EC 2.7.1.- ; FLJ12171; FN3K related protein; FN3K-related protein; FN3K-RP; FN3KL; Fn3krp; Fn3krp fructosamine-3-kinase-related protein; FN3X; Fructosamine-3-kinase-related protein; Ketosamine-3-kinase; KT3K_HUMAN; MGC40640; RGD1304570; RP23-293H17.3; Testis secretory sperm binding protein Li 211a

Target Background

A high concentration of glucose can result in non-enzymatic oxidation of proteins by reaction of glucose and lysine residues (glycation). Proteins modified in this way are less active or functional. This gene encodes an enzyme which catalyzes the phosphorylation of psicosamines and ribulosamines compared to the neighboring gene which encodes a highly similar enzyme, fructosamine-3-kinase, which has different substrate specificity. The activity of both enzymes may result in deglycation of proteins to restore their function. Alternative splicing results in multiple transcript variants.