Recombinant Human Kin of IRRE-like protein 3 (KIRREL3), Truncated

Uniprot Id

Q8IZU9

Target Species

Human

Target Name

KIRREL3

Target Full Name

Kin of IRRE-like protein 3

Target Function

Synaptic adhesion molecule required for the formation of target-specific synapses. Required for formation of target-specific synapses at hippocampal mossy fiber synapses. Required for formation of mossy fiber filopodia, the synaptic structures connecting dentate granule and GABA neurons. Probably acts as a homophilic adhesion molecule that promotes trans-cellular interactions and stabilize mossy fiber filipodia contact and subsequent synapse formation. Required for the coalescence of vomeronasal sensory neuron axons. May be involved in the hematopoietic supportive capacity of stroma cells; the secreted extracellular domain is directly responsible for supporting hematopoietic stem cells.

Target Involvement

Mental retardation, autosomal dominant 4 (MRD4)

Target Subcellular Location

Cell membrane; Single-pass type I membrane protein.; [Processed kin of IRRE-like protein 3]: Secreted.

Target Protein Families

Immunoglobulin superfamily

Target Tissue Specificity

Expressed in fetal and adult brain. Also expressed in kidney, specifically in podocytes of kidney glomeruli. Also expressed in skeletal muscle.

Target Synonyms

KIRREL3; KIAA1867; NEPH2; UNQ5923/PRO4502/PRO19814Kin of IRRE-like protein 3; Kin of irregular chiasm-like protein 3; Nephrin-like protein 2) [Cleaved into: Processed kin of IRRE-like protein 3]