Recombinant Human Kinesin-1 heavy chain (KIF5B), Truncated

Cat.No	ACP00853	Target Name	KIF5B
Target Synonyms	(Conventional kinesin heavy chain)(Ubiquitous kinesin heavy chain)(UKHC)	Form	Liquid or Lyophilized powder
Expression System	E.coli	Expression Range	1-431aa
Mol Weight	54.9 kDa	Protein Length	Partial
Purity	Greater than 85% as determined by SDS-PAGE.	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP00853

Target Name

KIF5B

Target Synonyms

(Conventional kinesin heavy chain)(Ubiquitous kinesin heavy chain)(UKHC)

Form

Liquid or Lyophilized powder

Expression System

E.coli

Expression Range

1-431aa

Mol Weight

54.9 kDa

Protein Length

Partial

Purity

Greater than 85% as determined by SDS-PAGE.

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	P33176

Background Information

Uniprot Id

P33176
Target Species

Human
Target Name

KIF5B
Target Full Name

Kinesin-1 heavy chain
Target Function

Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner. Regulates centrosome and nuclear positioning during mitotic entry. During the G2 phase of the cell cycle in a BICD2-dependent manner, antagonizes dynein function and drives the separation of nuclei and centrosomes. Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation. Through binding with PLEKHM2 and ARL8B, directs lysosome movement toward microtubule plus ends (Probable). Involved in NK cell-mediated cytotoxicity. Drives the polarization of cytolytic granules and microtubule-organizing centers (MTOCs) toward the immune synapse between effector NK lymphocytes and target cells.
Target Subcellular Location

Cytoplasm, cytoskeleton. Cytolytic granule membrane. Lysosome membrane; Peripheral membrane protein; Cytoplasmic side.
Target Protein Families

TRAFAC class myosin-kinesin ATPase superfamily, Kinesin family, Kinesin subfamily
Target Research Area

Cancer
Target Synonyms

Conventional kinesin heavy chain; KIF 5B; KIF5B; Kinesin 1 ; kinesin 1 (110-120kD); Kinesin 1 heavy chain; Kinesin family member 5B; Kinesin heavy chain; kinesin; heavy chain; ubiquitous; Kinesin-1 heavy chain; Kinesin1; KINH; KINH_HUMAN; KNS 1; KNS; KNS1; Ubiquitous kinesin heavy chain; UKHC
Target Background

Enables identical protein binding activity; microtubule binding activity; and microtubule motor activity. Involved in several processes, including lysosome localization; natural killer cell mediated cytotoxicity; and positive regulation of protein localization to plasma membrane. Located in centriolar satellite; cytosol; and vesicle.

Recombinant Human Kinesin-1 heavy chain (KIF5B), Truncated

Specifications

Immunogen Information

Inquire Recombinant Human Kinesin-1 heavy chain (KIF5B), Truncated Now

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