Recombinant Human Kinesin-associated protein 3 (KIFAP3)

Uniprot Id

Q92845

Target Species

Human

Target Name

KIFAP3

Target Full Name

Kinesin-associated protein 3

Target Function

Involved in tethering the chromosomes to the spindle pole and in chromosome movement. Binds to the tail domain of the KIF3A/KIF3B heterodimer to form a heterotrimeric KIF3 complex and may regulate the membrane binding of this complex.

Target Synonyms

FLJ22818; KAP 3; KAP-3; KAP3; KIF3AP; KIFA3_HUMAN; Kifap3; Kinesin associated protein 3; Kinesin-associated protein 3; SMAP; Smg GDS; Smg GDS associated protein; Smg GDS-associated protein

Target Background

The small G protein GDP dissociation stimulator (smg GDS) is a regulator protein having two activities on a group of small G proteins including the Rho and Rap1 family members and Ki-Ras; one is to stimulate their GDP/GTP exchange reactions, and the other is to inhibit their interactions with membranes. The protein encoded by this gene contains 9 'Armadillo' repeats and interacts with the smg GDS protein through these repeats. This protein, which is highly concentrated around the endoplasmic reticulum, is phosphorylated by v-src, and this phosphorylation reduces the affinity of the protein for smg GDS. It is thought that this protein serves as a linker between human chromosome-associated polypeptide (HCAP) and KIF3A/B, a kinesin superfamily protein in the nucleus, and that it plays a role in the interaction of chromosomes with an ATPase motor protein. Several transcript variants encoding different isoforms have been found for this gene.