Recombinant Human Kinesin-like protein KIF20A (KIF20A), Truncated

Uniprot Id

O95235

Target Species

Human

Target Name

KIF20A

Target Full Name

Kinesin-like protein KIF20A

Target Function

Mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. Following phosphorylation by PLK1, involved in recruitment of PLK1 to the central spindle. Interacts with guanosine triphosphate (GTP)-bound forms of RAB6A and RAB6B. May act as a motor required for the retrograde RAB6 regulated transport of Golgi membranes and associated vesicles along microtubules. Has a microtubule plus end-directed motility.

Target Subcellular Location

Golgi apparatus. Cytoplasm, cytoskeleton, spindle.

Target Protein Families

TRAFAC class myosin-kinesin ATPase superfamily, Kinesin family

Target Synonyms

AA415432; FLJ21151; GG10 2; GG10_2; KI20A_HUMAN; KIF20A; kinesin family member 20A; Kinesin like protein KIF20A; Kinesin-like protein 174; Kinesin-like protein KIF20A; mitotic kinesin like protein 2; Mitotic kinesin-like protein 2; MKlp2; OTTHUMP00000159481; RAB6 interacting; kinesin like (rabkinesin6); Rab6-interacting kinesin-like protein; RAB6-INTERACTING PROTEIN; KINESIN-LIKE; RAB6KIFL; Rabkinesin 6; Rabkinesin-6

Target Background

Enables protein kinase binding activity. Involved in microtubule bundle formation; midbody abscission; and regulation of cytokinesis. Located in several cellular components, including cleavage furrow; intercellular bridge; and midbody. Implicated in restrictive cardiomyopathy.