Recombinant Human Kinetochore-associated protein NSL1 homolog (NSL1)

Uniprot Id

Q96IY1

Target Species

Human

Target Name

NSL1

Target Full Name

Kinetochore-associated protein NSL1 homolog

Target Function

Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis.

Target Subcellular Location

Nucleus. Chromosome, centromere, kinetochore. Note=Associated with the kinetochore (PubMed:15502821, PubMed:16585270).

Target Synonyms

4833432M17Rik; AI451597; C1orf48; DC31; DC8; DKFZp566O1646; Gm105; Gm984; Kinetochore associated protein NSL1 homolog; Kinetochore-associated protein NSL1 homolog; MIS14; NSL1; NSL1, MIND kinetochore complex component, homolog (S. cerevisiae); NSL1_HUMAN

Target Background

This gene encodes a protein with two coiled-coil domains that localizes to kinetochores, which are chromosome-associated structures that attach to microtubules and mediate chromosome movements during cell division. The encoded protein is part of a conserved protein complex that includes two chromodomain-containing proteins and a component of the outer plate of the kinetochore. This protein complex is proposed to bridge centromeric heterochromatin with the outer kinetochore structure. Multiple transcript variants encoding different isoforms have been found for this gene. There is a pseudogene of the 3' UTR region of this gene on chromosome X.