Recombinant Human Kinetochore protein Nuf2 (NUF2)

Uniprot Id

Q9BZD4

Target Species

Human

Target Name

NUF2

Target Full Name

Kinetochore protein Nuf2

Target Function

Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules.

Target Subcellular Location

Nucleus. Chromosome, centromere, kinetochore. Note=Localizes to kinetochores from late prophase to anaphase. Localizes specifically to the outer plate of the kinetochore. NDC80 is required for efficient kinetochore localization.

Target Protein Families

NUF2 family

Target Synonyms

Cancer/testis antigen 106; CDCA 1; CDCA1; Cell division cycle associated 1; Cell division cycle associated protein 1; Cell division cycle-associated protein 1; CT106; hNuf 2; hNuf2; hNuf2R; hsNuf2; Kinetochore protein Nuf2; Nuf 2; NUF2; NUF2 NDC80 kinetochore complex component ; NUF2 NDC80 kinetochore complex component homolog ; NUF2, S. cerevisiae, homolog of; NUF2_HUMAN; NUF2R

Target Background

This gene encodes a protein that is highly similar to yeast Nuf2, a component of a conserved protein complex associated with the centromere. Yeast Nuf2 disappears from the centromere during meiotic prophase when centromeres lose their connection to the spindle pole body, and plays a regulatory role in chromosome segregation. The encoded protein is found to be associated with centromeres of mitotic HeLa cells, which suggests that this protein is a functional homolog of yeast Nuf2. Alternatively spliced transcript variants that encode the same protein have been described.