Recombinant Human Krueppel-like factor 7 (KLF7)

Uniprot Id

O75840

Target Species

Human

Target Name

KLF7

Target Full Name

Krueppel-like factor 7

Target Function

Transcriptional factor. Plays a critical role in neuronal morphogenesis and survival of sensory neurons. Represses the corneal epithelium differentiation. Acts also as a metabolic regulator, by modulating insulin sensitivity in pancreatic beta cells and skeletal muscle cells. Inhibits transcriptional inducers of adipogenesis and has a repressive role in the expression of several adipokines, including leptin.

Target Subcellular Location

Nucleus.

Target Protein Families

Krueppel C2H2-type zinc-finger protein family

Target Tissue Specificity

Widely expressed.

Target Synonyms

KLF7; KLF7_HUMAN; Krueppel like factor 7; Krueppel-like factor 7; Kruppel like factor 7; Ubiquitous krueppel like factor ; Ubiquitous krueppel-like factor; UKLF

Target Background

The protein encoded by this gene is a member of the Kruppel-like transcriptional regulator family. Members in this family regulate cell proliferation, differentiation and survival and contain three C2H2 zinc fingers at the C-terminus that mediate binding to GC-rich sites. This protein may contribute to the progression of type 2 diabetes by inhibiting insulin expression and secretion in pancreatic beta-cells and by deregulating adipocytokine secretion in adipocytes. A pseudogene of this gene is located on the long arm of chromosome 3. Alternative splicing results in multiple transcript variants.