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The expression region of this recombinant Human KYNU covers amino acids 1-307. This KYNU protein is expected to have a theoretical molecular weight of 61.6 kDa. This protein is generated in a e.coli-based system. Fusion of the N-terminal GST tag into the KYNU encoding gene fragment was conducted, allowing for easier detection and purification of the KYNU protein in subsequent stages.human kynureninase (KYNU) is a crucial enzyme in the tryptophan catabolic pathway, catalyzing the conversion of kynurenine to anthranilic acid. KYNU plays a pivotal role in regulating the levels of neuroactive kynurenine metabolites, influencing neurotransmission and immune responses. In neurobiology, KYNU is implicated in neurodegenerative diseases and psychiatric disorders due to its involvement in kynurenine metabolism. In immunology research, KYNU modulates immune tolerance and inflammation. Furthermore, KYNU's role in cancer metabolism underscores its significance in oncology. Investigating KYNU provides insights into tryptophan metabolism, offering potential applications in neurology, immunology, and cancer research, with implications for therapeutic strategies targeting these pathways.
The expression region of this recombinant Human KYNU covers amino acids 1-307. This KYNU protein is expected to have a theoretical molecular weight of 61.6 kDa. This protein is generated in a e.coli-based system. Fusion of the N-terminal GST tag into the KYNU encoding gene fragment was conducted, allowing for easier detection and purification of the KYNU protein in subsequent stages.human kynureninase (KYNU) is a crucial enzyme in the tryptophan catabolic pathway, catalyzing the conversion of kynurenine to anthranilic acid. KYNU plays a pivotal role in regulating the levels of neuroactive kynurenine metabolites, influencing neurotransmission and immune responses. In neurobiology, KYNU is implicated in neurodegenerative diseases and psychiatric disorders due to its involvement in kynurenine metabolism. In immunology research, KYNU modulates immune tolerance and inflammation. Furthermore, KYNU’s role in cancer metabolism underscores its significance in oncology. Investigating KYNU provides insights into tryptophan metabolism, offering potential applications in neurology, immunology, and cancer research, with implications for therapeutic strategies targeting these pathways.
| Cat.No | ACP02128 | Target Name | KYNU |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | E.coli |
| Expression Range | 1-307aa | Mol Weight | 61.6 kDa |
| Protein Length | Full Length of Isoform 2 | Purity | Greater than 90% as determined by SDS-PAGE. |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q16719 |
|---|
Uniprot Id
Q16719
Target Species
Human
Target Name
KYNU
Target Full Name
Kynureninase
Target Function
Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity.
Target Involvement
Hydroxykynureninuria (HYXKY); Vertebral, cardiac, renal, and limb defects syndrome 2 (VCRL2)
Target Subcellular Location
Cytoplasm, cytosol.
Target Protein Families
Kynureninase family
Target Tissue Specificity
Expressed in all tissues tested (heart, brain placenta, lung, liver, skeletal muscle, kidney and pancreas). Highest levels found in placenta, liver and lung. Expressed in all brain regions.
Target Research Area
Signal Transduction
Target Synonyms
kynU; KYNU_HUMAN; kynureninase (L-kynurenine hydrolase); Kynureninase; L-kynurenine hydrolase
Target Background
Kynureninase is a pyridoxal-5'-phosphate (pyridoxal-P) dependent enzyme that catalyzes the cleavage of L-kynurenine and L-3-hydroxykynurenine into anthranilic and 3-hydroxyanthranilic acids, respectively. Kynureninase is involved in the biosynthesis of NAD cofactors from tryptophan through the kynurenine pathway. Alternative splicing results in multiple transcript variants.
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