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Recombinant Human Leucine-rich repeat-containing protein 25 (LRRC25), Truncated

ACP12833

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Specifications

Cat.No	ACP12833	Target Name	LRRC25
Target Synonyms	LRRC25; MAPA; UNQ6169/PRO20174Leucine-rich repeat-containing protein 25; Monocyte and plasmacytoid-activated protein	Form	Lyophilized powder
Expression System	Custom Production. Please inquire and provide the desire expression system.	Protein Length	Partial
Purity	>85% (SDS-PAGE)	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information

Target Species	Human	Uniprot ID	Q8N386

Background Information

Uniprot Id

Q8N386
Target Species

Human
Target Name

LRRC25
Target Full Name

Leucine-rich repeat-containing protein 25
Target Function

Plays a role in the inhibition of RLR-mediated type I interferon signaling pathway by targeting DDX58/RIG-I for autophagic degradation. Interacts specifically with ISG15-associated DDX58 to promote interaction between DDX58 and the autophagic cargo receptor p62/SQSTM1 to mediate DDX58 degradation via selective autophagy. Plays also a role in the inhibition of NF-kappa-B signaling pathway and inflammatory response by promoting the degradation of p65/RELA.
Target Subcellular Location

Membrane; Single-pass type I membrane protein. Cytoplasm.
Target Tissue Specificity

Expressed in plasmacytoid dendritic cells (PDC), monocyte-derived dendritic cells (MDDC), granulocytes, monocytes, B-lymphocytes, peripheral blood leukocytes, spleen, bone marrow, and, to a lesser extent, lymph nodes, fetal liver, and appendix but not in
Target Synonyms

LRRC25; MAPA; UNQ6169/PRO20174Leucine-rich repeat-containing protein 25; Monocyte and plasmacytoid-activated protein

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Recombinant Human Leucine-rich repeat-containing protein 25 (LRRC25), Truncated

Specifications

Immunogen Information

Inquire Recombinant Human Leucine-rich repeat-containing protein 25 (LRRC25), Truncated Now

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