Recombinant Human Leucine-rich repeat-containing protein 8C (LRRC8C), Truncated

Uniprot Id

Q8TDW0

Target Species

Human

Target Name

LRRC8C

Target Full Name

Volume-regulated anion channel subunit LRRC8C

Target Function

Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine. Plays a redundant role in the efflux of amino acids, such as aspartate and glutamate, in response to osmotic stress. The VRAC channel also mediates transport of immunoreactive cyclic dinucleotide GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol. Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition.

Target Subcellular Location

Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane.

Target Protein Families

LRRC8 family

Target Tissue Specificity

Expressed at highest levels in skeletal muscle, and at moderate levels in heart, lung and peripheral blood leukocytes.

Target Synonyms

AD158; AI326115; E430036I04Rik; Factor for adipocyte differentiation 158; FAD158; Leucine-rich repeat-containing protein 8C; LRC8C_HUMAN; LRRC8C