Recombinant Human Leucine-rich repeat-containing protein 8D (LRRC8D), Truncated

Uniprot Id

Q7L1W4

Target Species

Human

Target Name

LRRC8D

Target Full Name

Volume-regulated anion channel subunit LRRC8D

Target Function

Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine. Plays a redundant role in the efflux of amino acids, such as aspartate, in response to osmotic stress. LRRC8A and LRRC8D are required for the uptake of the drug cisplatin. Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition. Also acts as a regulator of glucose-sensing in pancreatic beta cells: VRAC currents, generated in response to hypotonicity- or glucose-induced beta cell swelling, depolarize cells, thereby causing electrical excitation, leading to increase glucose sensitivity and insulin secretion. VRAC channels containing LRRC8D inhibit transport of immunoreactive cyclic dinucleotide GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol. Mediates the import of the antibiotic blasticidin-S into the cell.

Target Subcellular Location

Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.

Target Protein Families

LRRC8 family

Target Synonyms

LRRC8D; LRRC5; UNQ213/PRO239; Volume-regulated anion channel subunit LRRC8D; Leucine-rich repeat-containing protein 5; Leucine-rich repeat-containing protein 8D