Recombinant Human Leucine-rich repeat protein SHOC-2 (SHOC2)

Uniprot Id

Q9UQ13

Target Species

Human

Target Name

SHOC2

Target Full Name

Leucine-rich repeat protein SHOC-2

Target Function

Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the 'Ser-259' inhibitory site of RAF1 kinase and stimulate RAF1 activity at specialized signaling complexes.

Target Involvement

Noonan syndrome-like disorder with loose anagen hair 1 (NSLH1)

Target Subcellular Location

Cytoplasm. Nucleus.

Target Protein Families

SHOC2 family

Target Synonyms

KIAA0862; Leucine-rich repeat protein SHOC-2; Protein soc-2 homolog; Protein Sur-8 homolog; Ras-binding protein Sur-8; SHOC2; SHOC2_HUMAN

Target Background

This gene encodes a protein that consists almost entirely of leucine-rich repeats, a domain implicated in protein-protein interactions. The protein may function as a scaffold linking RAS to downstream signal transducers in the RAS/ERK MAP kinase signaling cascade. Mutations in this gene have been associated with Noonan-like syndrome with loose anagen hair.