Recombinant Human Lipocalin-1 (LCN1)

Uniprot Id

P31025

Target Species

Human

Target Name

LCN1

Target Full Name

Lipocalin-1

Target Function

Could play a role in taste reception. Could be necessary for the concentration and delivery of sapid molecules in the gustatory system. Can bind various ligands, with chemical structures ranging from lipids and retinoids to the macrocyclic antibiotic rifampicin and even to microbial siderophores. Exhibits an extremely wide ligand pocket.

Target Subcellular Location

Secreted.

Target Protein Families

Calycin superfamily, Lipocalin family

Target Tissue Specificity

Mainly expressed in lachrymal and salivary glands. Also expressed in the prostate.

Target Research Area

Cell Biology

Target Synonyms

LCN1; LCN1_HUMAN; Lipocalin 1 (protein migrating faster than albumin, tear prealbumin); Lipocalin 1 like 2; Lipocalin-1; PMFA ; Tear lipocalin; Tear prealbumin; Tlc; TP; VEG protein; VEGP ; Von Ebner gland protein

Target Background

This gene encodes a member of the lipocalin family of small secretory proteins. Lipocalins are extracellular transport proteins that bind to a variety of hydrophobic ligands. The encoded protein is the primary lipid binding protein in tears and is overproduced in response to multiple stimuli including infection and stress. The encoded protein may be a marker for chromosome aneuploidy as well as an autoantigen in Sjogren's syndrome. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and two pseudogenes of this gene are also located on the long arm of chromosome 9.