Recombinant Human Low affinity immunoglobulin gamma Fc region receptor II-c (FCGR2C), Truncated

Uniprot Id

P31995

Target Species

Human

Target Name

FCGR2C

Target Full Name

Low affinity immunoglobulin gamma Fc region receptor II-c

Target Function

Receptor for the Fc region of complexed immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells.

Target Subcellular Location

[Isoform IIC4]: Cytoplasm.; [Isoform IIC3]: Cell membrane; Single-pass type I membrane protein.; [Isoform IIC2]: Cell membrane; Single-pass type I membrane protein.; [Isoform IIC1]: Cell membrane; Single-pass type I membrane protein.

Target Tissue Specificity

Isoform IIC1 is detected in monocytes, macrophages, polymorphonuclear cells and natural killer cells.

Target Synonyms

FCGR2C; CD32; FCG2; IGFR2; Low affinity immunoglobulin gamma Fc region receptor II-c; IgG Fc receptor II-c; CDw32; Fc-gamma RII-c; Fc-gamma-RIIc; FcRII-c; CD antigen CD32

Target Background

This gene encodes one of three members of a family of low-affinity immunoglobulin gamma Fc receptors found on the surface of many immune response cells. The encoded protein is a transmembrane glycoprotein and may be involved in phagocytosis and clearing of immune complexes. An allelic polymorphism in this gene results in both coding and non-coding variants.