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| Cat.No | ACP01610 | Target Name | FCGR3B |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | E.coli |
| Expression Range | 18-125aa | Mol Weight | 47.5 kDa |
| Protein Length | Partial | Purity | Greater than 85% as determined by SDS-PAGE. |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | O75015 |
|---|
Uniprot Id
O75015
Target Species
Human
Target Name
FCGR3B
Target Full Name
Low affinity immunoglobulin gamma Fc region receptor III-B
Target Function
Receptor for the Fc region of immunoglobulins gamma. Low affinity receptor. Binds complexed or aggregated IgG and also monomeric IgG. Contrary to III-A, is not capable to mediate antibody-dependent cytotoxicity and phagocytosis. May serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils.
Target Subcellular Location
Cell membrane; Lipid-anchor, GPI-anchor. Secreted. Note=Secreted after cleavage.
Target Tissue Specificity
Expressed specifically by polymorphonuclear leukocytes (neutrophils). Also expressed by stimulated eosinophils.
Target Research Area
Immunology
Target Synonyms
CD16; CD16b; CD16b antigen ; Fc fragment of IgG low affinity IIIb receptor; Fc gamma receptor IIIb; Fc gamma RIII; Fc gamma RIII beta; Fc gamma RIIIb; Fc-gamma RIII; Fc-gamma RIII-beta; Fc-gamma RIIIb; FCG3; FCG3B_HUMAN; FCGR3; FCGR3B; FcR 10; FcR-10; FcR10; FcRIII; FcRIIIb; IGFR3; IgG Fc receptor III 1; IgG Fc receptor III-1; Low affinity immunoglobulin gamma Fc region receptor III B; Low affinity immunoglobulin gamma Fc region receptor III-B
Target Background
The protein encoded by this gene is a low affinity receptor for the Fc region of gamma immunoglobulins (IgG). The encoded protein acts as a monomer and can bind either monomeric or aggregated IgG. This gene may function to capture immune complexes in the peripheral circulation. Several transcript variants encoding different isoforms have been found for this gene. A highly-similar gene encoding a related protein is also found on chromosome 1.
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